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An a1-AR antagonist binds to a1-ARs in rat brain membranes (Ki 12.5 nM) inhibits a1-AR agonist-induced contractions in endothelium-denuded isolated rat aortic rings and perfused mesenteric vascular beds (pA2s 8.6 and 11.1 respectively) inhibits cirazoline-induced pressor responses in rats at 0.5 Ug/kg per minute i.v. improves postischemic glutamate uptake and reduces neuronal cell death and mortality in a rat model of global brain ischemia induced by mild hyperthermia at 32 mg/kg increases corneal NGF levels and accelerates corneal wound healing in a rat model of ocular injury
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
An a1-AR antagonist binds to a1-ARs in rat brain membranes (Ki 12.5 nM) inhibits a1-AR agonist-induced contractions in endothelium-denuded isolated rat aortic rings and perfused mesenteric vascular beds (pA2s 8.6 and 11.1 respectively) inhibits cirazoline-induced pressor responses in rats at 0.5 Ug/kg per minute i.v. improves postischemic glutamate uptake and reduces neuronal cell death and mortality in a rat model of global brain ischemia induced by mild hyperthermia at 32 mg/kg increases corneal NGF levels and accelerates corneal wound healing in a rat model of ocular injury
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More